Chercheur postdoctoral

Updated: April 12, 2024 04:55 AM GMT

Université de Rennes

Rennes

https://igdr.univ-rennes.fr/offre-de-post-doctorat-rennes

Call for a Post-doctoral position in Rennes, Brittany (FRANCE): Molecular mechanisms underlying developmental disorders associated with Sonic Hedgehog Signaling Pathway”

Funded by the French Research Agency (ANR), the collaborative research project DISPHPE focuses on Sonic Hedgehog (SHH) a signaling pathway, that plays a key role in the dorso-ventral regionalisation of the brain. Genetics is the main component of forebrain midline defects, with alterations leading to a decrease in the SHH pathway. The inaccessibility of the affected tissues is a major obstacle to in-depth knowledge of pathophysiological mechanisms and improved molecular diagnosis in humans. Approaches to differentiating human induced pluripotent stem cells (hiPSCs) into physiologically relevant tissues offer a unique opportunity to overcome these limitations. Our work aims to recapitulate the developmental characteristics and function of tissues in order to... More Detail